Virus infections in children with acute lymphoblastic leukaemia.

Complement fixing antibody responses to virus infection in children with acute lymphoblastic leukaemia.

Thirty children with acute lymphoblastic leukaemia (ALL) were studied and had a virus isolated. Only 50% produced a significant rise in complement fixing (CF) antibody titre compared to 100% of normal children. The failure to produce antibodies was unpredictable. CF antibodies are not a reliable guide to virus infections in children with ALL.

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

Investigating the effect of seasonality of birth for acute lymphoblastic leukaemia

The investigation of the seasonality of a disease is an important objective in many epidemiological studies. Two statistical methods (Edwards' and Walter-Elwood methods) are described here to detect cyclic trends in time of birth of children diagnosed with acute lymphoblastic leukaemia (ALL) aged 0 4 year . We found evidence of seasonality related to month of birth with peaks in February and Au...

EB-virus-specific IgM and IgG antibodies in first-degree relatives of children with acute lymphoblastic leukaemia.

EB-virus-specific IgM and IgG antibodies (to virus capsid and soluble complement fixing antigens) were estimated in sera from mothers and sibs of children with acute lymphoblastic leukaemia, from patients with infectious mononucleosis, and from control induviduals. IgM antibodies were present in 12 of 16 mothers and 3 of 4 sibs of children with acute lymphoblastic leukaemia. They were also pres...

Immune response in families of children with acute lymphoblastic leukaemia.

Evans, D. I. K. (1973). Archives of Disease in Childhood, 48, 441. Immune response in families of children with acute lymphoblastic leukaemia. The immune status of 33 mothers, 17 fathers, and 14 sibs of children with acute lymphoblastic leukaemia was studied with the following tests: peripheral blood lymphocyte counts, lymphocyte transformation with phytohaemagglutinin, serum immunoglobulin lev...